Photo Credit: Harsh Patel

Clemson Football Opponent Preview – Louisville Cardinals

Maybe it’s because our Clemson Tigers football team won, but I thoroughly enjoyed last weekend’s win against Florida State.  Wins against Florida State have become common over the past 10+ years, but that was not always the case, especially when I was in school all those years ago.  So I’ve come to cherish every victory against those guys.

It’s no secret that the Tigers needed that victory.  The two bell cows of the ACC having out-of-character seasons, but selfishly, I think Clemson needed it and wanted it more.  And they got it.

It also seemed to light a fire under the team and staff this week, in the lead up to the ACC Friday Night tilt against a very good Louisville Cardinals team.  A loss last week, and our Tigers are likely tucking their tails and taking a beating up there on the Bourbon Trail.  

But there is a little hitch in the giddy-up around Clemson this week, and here’s to hoping the team shows up, plays hard, and comes back home with successive wins.  

Here is a look at everything you will need to know about the Tiger’s Week 12 Opponent, the Louisville Cardinals:

Louisville Cardinals

School Location: Louisville, Kentucky

Game Location: L&N Federal Credit Union Stadium

Time: Friday 7:30PM; ESPN

2025 Record – 7-2; (4-2 ACC)  

Wins Against: Eastern Kentucky, James Madison, Bowling Green, Pitt, Miami, Boston College, Virginia Tech

Losses against: Virginia, Cal

Head Coach: Jeff Brohm – 3rd Season

Coach Jeff Brohm coaches like a guy who keeps a Red Bull in one hand and a play sheet in the other. In true Brohm fashion, Louisville mixes aggressive, QB-friendly offense with disciplined, stingy defense, and somehow makes it look easy. He loves motion, misdirection, and chunk plays,  the kind that make defensive coordinators question their life choices. And defensively? His teams hit like they’re mad someone doubted them. It’s fast, fearless, and fully Coach Brohm’s personality. 

Offense

Offensive Coordinator: Brian Brohm – 3rd year as OC –  Previous: Purdue Co-OC

Coach Brian Brohm runs Louisville’s offense like a former star quarterback who still sees the field better than everyone else because he does. His play calling blends smooth efficiency with sneaky aggression, using motion, layered routes, and perfectly timed shot plays that leave defenders flat footed. He builds early rhythm for his quarterback, keeps the run game honest, and then picks his moments to drop the big play on you. It is smart, sharp, creative, and very much Brohm family football.

Louisville has averaged 32.9 points their first nine games of the season (T-35th; Clemson is 68th; 27.9 ppg) with 154.9 yards rushing per game (70th; Clemson is 112th; 120.9 yds/game) and 246.6 yards through the air (48th; Clemson: 14th; 288.4 yds/game) for a total of 401.5 yards of offense per game through nine games (58th; Clemson: 51st; 409.3 yds/game)

Here is a look at the projected starters for the Louisville Cardinals from their released depth chart as well as their 2025 statistics through their nine games:

QuarterbackMiller Moss (USC)RS Senior#739 attempts, -73 yds, 7 TDs197-309; 63.75%; 2132 yds, 11 TD, 7 Ints
Running BackIsaac BrownSophomore#191 att. 782 yds, 5 TDs 11 catches, 42 yds
Wide ReceiverChris BellSenior#062 catches, 792 yds, 6 TDs
Wide ReceiverCaullin Lacy (South Alabama)RS Senior#510 att. 19 yds48 catches, 482 yds, 2 TDs
Wide ReceiverTreyshun Hurry (San Jose St/Weber St)RS Junior#29 catches, 61 yds
Tight EndNate KuriskyRS Junior#8516 catches, 139 yds, TD
Left TackleTrevonte Sylvester (Houston)RS Senior#70
Left GuardLance Robinson (Houston/MTSU)RS Senior#53
CenterPete Nygra (Northern Illinois)RS Senior#50
Right GuardMahamane Moussa (Purdue)RS Senior#71
Right TackleRasheed Miller (Georgia Southern)RS Senior#60

Defense

Defensive Coordinators: Ron English/Mark Hagen – 3rd Seasons – Previous: Purdue Co-DCs

Coaches Mark Hagen and Ron English run Louisville’s defense like two veteran chess players who already know your next move and are happy to make you prove them wrong. Their style mixes physical front seven play with smart coverage on the back end, creating a defense that squeezes space and forces quarterbacks into rushed decisions. They love pressure, disguise, and disciplined tackling. The result is a unit that plays fast, hits hard, and rarely gives you anything easy.

The Louisville defense has given up 21.7 points through their nine games (41st; Clemson: 54th; 22.4 pts/game).  They have given up an average of 108.7 yards on the ground (22nd; Clemson: 19th; 106.2 yds/game) and 188.1 yards through the air (27th; Clemson: 107th; 245.1 yds/game). The Cardinals are giving up a total of 296.8 yards thus far (14th; Clemson: 54th; 351.3 yds/game). 

Here is a look at the projected starters for the Cards on defense along with stats from the their first nine games:

Defensive EndClev Lubin (Coastal Carolina/Army)RS Junior#5044 tackles, 6.5 TFLs, 4 sacks, FF
Nose TackleJordan Guerad (Florida International)RS Senior#9921 tackles, 4 TFLs, 1.5 sacks, Int
Defensive TackleRene Konga (Rutgers)RS Senior#9024 tackles, 5 TFLs, 1.5 sacks
Defensive EndWes Bailey (Rutgers)RS Senior#2334 tackles, 6 TFLs, 5 sacks
Strongside LinebackerAntonio WattsRS Junior#935 tackles, 5.5 TFLs, 2 sacks, 3 Ints, FF, FR
Middle LinebackerKalib Perry (Tennessee)Senior#1240 tackles, 1.5 TFLs, Int
Weakside LinebackerTJ QuinnRS Senior#3467 tackles, 4 TFLs, sack, 2 Ints
CornerbackJabari Mack (Jacksonville State)Senior#423 tackles, 2 Ints
Strong SafetyD’Angelo HutchinsonSenior#2156 tackles, 2 TFLs, Int
Free SafetyJoJo Evans, Jr. (FIU/Kent St/Marshall)RS Senior#2745 tackles, 0.5 TFL, Int
Free SafetyCorey Gordon (Baylor)RS Junior#2427 tackles, TFL
CornerbackTayon Holloway (North Carolina)RS Junior#2530 tackles, 2.5 TFLs, 0.5 sack

Special Teams

Here is a list of the specialists for the Cardinals along with statistics from the 2025 Season:

KickerCooper RanvierRS Freshman#3615-17; long of 50 yds
PunterCarter SchwartzRS Sophomore#3940.2 yd avg.; long of 60 yds
Punt ReturnerCaullin Lacy (South Alabama)RS Senior#523.4 yd avg; 2 TDs, long of 93 yds
Kick ReturnerCaullin Lacy (South Alabama)RS Senior#521.2 yd avg; long of 40 yds

Turnovers

Louisville is Plus-2 (+2) in turnover margin so far, having lost 6 fumbles and having thrown 8 interceptions.  They have forced 4 opponent fumbles so far while intercepting 12 opponent passes.  Louisville has 14 turnovers to their opponents 16 through 9 games. 

Final Thought

Louisville inexplicably lost two games on their schedule that would normally be thought of as “laughers” (Cal and UVA), but still manage to be towards the top of the ACC.  

Louisville blasted our Tigers at Death Valley last season, in a game reminiscent of the 2012 Orange Bowl.  There was just no stopping the run game a season ago from the Cards and the Clemson offense could do next to nothing.  

Clemson’s offense seems to be hitting its stride, and the defense has put together two straight solid games.  Wild things happen on ACC Friday night games.  Let’s hope the something wild is a Clemson victory on the road. 

Enjoy the game. 

Stay up-to-date with all things Clemson sports by visiting Clemson Sports Media, your one-stop website for everything Clemson. We provide post-game interviews, in-depth analysis, and comprehensive coverage of all Clemson sports. Don’t miss out on the latest news and updates, visit Clemson Sports Media today.